Although primarily a terrestrial species, the white throated monitor will climb trees to hunt for prey, to reproduce, and to avoid predators (3). If confronted on the ground by a predator, such as a honey badger, it will puff up its throat and body, lash out with its tail, and bite violently (3) (5). During the summer it is active throughout the day, except during midday in regions where temperatures are extremely high (3). It hunts for a wide range of prey and will eat just about anything it can subdue, from snakes, birds and eggs, to snails, millipedes and grasshoppers (3) (5). Although the white-throated monitor remains alert during the winter months, it is far less active and generally remains in its overnight refuge, which usually takes the form of an earth burrow or hollow tree trunk (3).
During the breeding season, receptive females almost always climb into trees. Once a male locates a female, the pair will mate for one to two days before the male goes in search of another female (3). Each year, a female may lay two clutches of up to 50 eggs (5).