Like other Pristurus species, the Middle Eastern rock gecko is likely to be an ambush predator that hunts small invertebrates (3) (7). This species feeds mainly on ants, which are reported to constitute over 80 percent of its diet (7). Unusually among geckos, Pristurus species are mainly active during the day (4) (6) (7).
Mating in the Middle Eastern rock gecko occurs between June and July. A single egg is laid, either in the forks of branches or in deep holes in the ground, usually under sheltered rocks or vegetation or hidden beneath leaf litter (7). The eggs of this species are more or less spherical (6).
As in related species, the Middle Eastern rock gecko is likely to communicate using a series of specific tail movements to visually signal to other individuals (2) (5) (6). In other Pristurus species, the tail can be shaken horizontally or vertically or curled over the back (4) (5). The Middle Eastern rock gecko also communicates via a series of head nods. This species is very territorial and will aggressively defend an area from invading individuals (2).
When pursued by a predator, the Middle Eastern rock gecko is able to shed its tail, providing the predator with a distraction lasting long enough for the gecko to escape (5). The tail can then be entirely regenerated (7).