The jeweled chameleon is known to be collected from the wild for sale in the western pet markets, but insufficient data exists to fully understand the impact of this trade. However, probably the greatest threat to the species, and most important factor affecting the future survival of Madagascar's chameleons, is habitat loss as primary vegetation is cleared for conversion to subsistence agriculture (1).
The jeweled chameleon is listed on Appendix II of CITES, which regulates the volume of international trade in the species (1).