Typically solitary, due to limited food availability (7), the greater Egyptian gerbil is nocturnal, spending the daytime in a burrow (8). The burrow may have one to five entrances (2), which can be blocked with sand once the gerbil is inside (8).
Like many other gerbil species, the greater Egyptian gerbil forages at dusk and during the night for seeds (its preferred food) and other plant parts (2) (6). The greater Egyptian gerbil is known to store food reserves to cope with periods of food scarcity in its desert habitat; this often includes storing camel dung, which the gerbil picks through to find undigested seeds (2). It rarely ventures into open habitat because it is hunted by owls, but may also avoid shrubs due to the presence of snakes (9).
This species breeds between late winter and early spring, when increased rainfall boosts the amount of food available (10). The greater Egyptian gerbil gives birth to an average of four young at a time, after a gestation period of 25 days (4). The young, which are born naked and helpless with their eyes closed (5), are weaned after 25 to 30 days (8).