The giant-striped mongoose primarily feeds on invertebrates such as grasshoppers and scorpions, although it has been known to consume small birds, reptiles and occasionally mammals. Although invertebrates will be eaten throughout the year, the diet may vary between the wet season and the dry season, with vertebrates more likely to be eaten in the wet season (6).
A nocturnal species, the giant-striped mongoose will hunt and forage at night, either alone or in pairs (7) (5). During the day, this species usually takes refuge in cavernous holes in limestone formations to avoid the intense sunlight. The giant-striped mongoose does not always return to the same hole it occupied the previous day (7).
Little is known about the reproductive cycle of this species. It is likely to breed throughout the year, with the female producing one offspring annually (8) (7). The adult giant-striped mongoose is thought to breed in a monogamous pair, with both adults taking care of the young (7).
An individual giant-striped mongoose may have a home range of approximately one square kilometre (7). This species defecates at latrine sites, which are usually located on exposed rocks. It is thought these could be territorial markers (2). Not much else is known about the methods of communication used by giant-striped mongooses. Other mongooses communicate, using smell, body language and vocal signals, so it is likely the giant-striped mongoose communicates in a similar manner (7).
There are no known natural predators of the giant-striped mongoose. It is thought that the only potential predator is the fossa (Cryptoprocta ferox), a cat-like carnivore also native to Madagascar (7).