The Egyptian spiny-tailed lizard usually lives in colonies of several individuals, occupying an extensive territory. The deep burrows, which are used over many years, serve as a shelter from predators and from extreme desert conditions, and the lizard may hibernate in the burrow during winter months (3) (5). The Egyptian spiny-tailed lizard is active during the day, individuals basking at the burrow entrance to warm up before heading out to forage for leaves, buds, fruits, seeds and flowers (3) (5). The chisel-like teeth of this species are characteristic of agamid lizards, and, unlike in other lizards, are firmly fused to the jaw bones. In spiny-tailed lizards, the teeth wear down with age, and the bone develops sharp cutting edges (5) (7).
Mating in the Egyptian spiny-tailed lizard usually occurs around May (3), with the male performing complex courtship rituals to obtain matings (7). The female lays a single clutch of between 10 and 40 eggs, in May or June, in a deep burrow. The eggs hatch at the end of August. Juvenile Egyptian spiny-tailed lizards are very vulnerable to predation, with many killed during the first year by birds, other lizards or snakes. Those that survive reach sexual maturity at around 4 to 6 years (3), and can live for an impressive 33 years or more (8).