Little is known about the social behaviour of the Cairo spiny mouse, but it is thought to live in social groups (3). It is well adapted to survive in arid conditions and can reduce urine production by up to 90 percent to conserve water when necessary (3). It is a largely nocturnal animal and eats a varied diet, including insects, snails and seeds (3). Curiously, in Egypt this species has been reported to also feed on the dried flesh and bone marrow of mummified humans (6).
Reproduction in the Cairo spiny mouse is continuous; that is, there is no particular breeding season (3). Information on the breeding biology of the Cairo spiny mouse is scant, but it is likely to be similar to the closely related golden spiny mouse (Acomys russatus), which gives birth to litters of one to five young, each weighing up to seven grams (2). The gestation period of the Cairo spiny mouse is 39 days (3). The young, which are well-developed at birth, are probably weaned after about two weeks and reach maturity at about two to three months (2) (6). Spiny mice typically live for around three years (6).